Manolis Kellis: Human Genome and Evolutionary Dynamics | Lex Fridman Podcast #113

Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. He is interested in understanding the human genome from a computational, evolutionary, biological, and other cross-disciplinary perspectives.

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EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
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OUTLINE:
0:00 – Introduction
3:54 – Human genome
17:47 – Sources of knowledge
29:15 – Free will
33:26 – Simulation
35:17 – Biological and computing
50:10 – Genome-wide evolutionary signatures
56:54 – Evolution of COVID-19
1:02:59 – Are viruses intelligent?
1:12:08 – Humans vs viruses
1:19:39 – Engineered pandemics
1:23:23 – Immune system
1:33:22 – Placebo effect
1:35:39 – Human genome source code
1:44:40 – Mutation
1:51:46 – Deep learning
1:58:08 – Neuralink
2:07:07 – Language
2:15:19 – Meaning of life

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Comment (25)

  1. I really enjoyed this conversation with Manolis. Here's the outline:
    0:00 – Introduction
    3:54 – Human genome
    17:47 – Sources of knowledge
    29:15 – Free will
    33:26 – Simulation
    35:17 – Biological and computing
    50:10 – Genome-wide evolutionary signatures
    56:54 – Evolution of COVID-19
    1:02:59 – Are viruses intelligent?
    1:12:08 – Humans vs viruses
    1:19:39 – Engineered pandemics
    1:23:23 – Immune system
    1:33:22 – Placebo effect
    1:35:39 – Human genome source code
    1:44:40 – Mutation
    1:51:46 – Deep learning
    1:58:08 – Neuralink
    2:07:07 – Language
    2:15:19 – Meaning of life

  2. Don't worry Lex, I've got your back on the simulation theory as a thought experiment that helps me (as a junior programmer) to abstract the idea of things such as math and physics.
    Huge thanks for incredible Manolis and yourself 😁 loved the show!

  3. 22:45 "Wikipedia is pretty awesome." It is if you are a leftie shilling for the oligarchy, which is so controlling you can't even mention their name without getting censored and kicked off social media.

  4. 52:44 The asteroid did not strike "slightly north of Machu Picchu". The asteroid struck on the Yucatan Peninsula, slightly north of where the Mayan empire eventually arose in modern-day Mexico. Machu Picchu was built by the Incas, who lived thousands of miles away in the mountains of South America. Not even the same continent.

    Not particularly important to the podcast, but the historical inaccuracy annoys me. Especially when it comes to how little people seem to know or care about pre-Colombian American civilizations.

  5. 6:03 what's unique about the genome?
    16:43 effectively using the internet- teaching the basic "how-to"
    23:10 why is wikipedia hated so much?
    -ascertainment bias and writing bias
    (implications?)
    27:58 easier to figure the phenotype of something by mining this massive amount of human data than by going back to any other specie
    (reason?)
    29:15 free will?
    continue from 37:00

  6. "I am extremely grateful and feel extremely lucky to be living in the time that we are now. And, of all time in human history, this is probably the best time to be a human being and this might actually be the best way to be a human being."
    Completely accurate 💯👌🏽😌🥰🤩🌼🐛🌙🌟🌻😍🐝🦋🌷🥀🦄🐞🌸🌹✨💐

  7. Does it mean that if we put our brain in a body that for examples has 1 leg and 1 eye, or 4 arms and 10 legs, it will still find a way to control them and it'll become a valuable human that will fit in a society of similar "creatures"

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