Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. He is interested in understanding the human genome from a computational, evolutionary, biological, and other cross-disciplinary perspectives.
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I really enjoyed this conversation with Manolis. Here's the outline: 0:00 – Introduction 3:54 – Human genome 17:47 – Sources of knowledge 29:15 – Free will 33:26 – Simulation 35:17 – Biological and computing 50:10 – Genome-wide evolutionary signatures 56:54 – Evolution of COVID-19 1:02:59 – Are viruses intelligent? 1:12:08 – Humans vs viruses 1:19:39 – Engineered pandemics 1:23:23 – Immune system 1:33:22 – Placebo effect 1:35:39 – Human genome source code 1:44:40 – Mutation 1:51:46 – Deep learning 1:58:08 – Neuralink 2:07:07 – Language 2:15:19 – Meaning of life
I think Lex's podcasts with Manolis are definitely some of his best. You can just feel the passion he has for this stuff radiating from him. Very infectious.
Don't worry Lex, I've got your back on the simulation theory as a thought experiment that helps me (as a junior programmer) to abstract the idea of things such as math and physics. Huge thanks for incredible Manolis and yourself 😁 loved the show!
22:45 "Wikipedia is pretty awesome." It is if you are a leftie shilling for the oligarchy, which is so controlling you can't even mention their name without getting censored and kicked off social media.
52:44 The asteroid did not strike "slightly north of Machu Picchu". The asteroid struck on the Yucatan Peninsula, slightly north of where the Mayan empire eventually arose in modern-day Mexico. Machu Picchu was built by the Incas, who lived thousands of miles away in the mountains of South America. Not even the same continent.
Not particularly important to the podcast, but the historical inaccuracy annoys me. Especially when it comes to how little people seem to know or care about pre-Colombian American civilizations.
6:03 what's unique about the genome? 16:43 effectively using the internet- teaching the basic "how-to" 23:10 why is wikipedia hated so much? -ascertainment bias and writing bias (implications?) 27:58 easier to figure the phenotype of something by mining this massive amount of human data than by going back to any other specie (reason?) 29:15 free will? continue from 37:00
"I am extremely grateful and feel extremely lucky to be living in the time that we are now. And, of all time in human history, this is probably the best time to be a human being and this might actually be the best way to be a human being." Completely accurate 💯👌🏽😌🥰🤩🌼🐛🌙🌟🌻😍🐝🦋🌷🥀🦄🐞🌸🌹✨💐
Does it mean that if we put our brain in a body that for examples has 1 leg and 1 eye, or 4 arms and 10 legs, it will still find a way to control them and it'll become a valuable human that will fit in a society of similar "creatures"
I really enjoyed this conversation with Manolis. Here's the outline:
0:00 – Introduction
3:54 – Human genome
17:47 – Sources of knowledge
29:15 – Free will
33:26 – Simulation
35:17 – Biological and computing
50:10 – Genome-wide evolutionary signatures
56:54 – Evolution of COVID-19
1:02:59 – Are viruses intelligent?
1:12:08 – Humans vs viruses
1:19:39 – Engineered pandemics
1:23:23 – Immune system
1:33:22 – Placebo effect
1:35:39 – Human genome source code
1:44:40 – Mutation
1:51:46 – Deep learning
1:58:08 – Neuralink
2:07:07 – Language
2:15:19 – Meaning of life
There you go… Corona virus wasn’t manufactured
Manolos is fascinating!!
I think Lex's podcasts with Manolis are definitely some of his best. You can just feel the passion he has for this stuff radiating from him. Very infectious.
This is the type of guy who would call a Xenomorph the perfect organism. "I admire it's purity".
Don't worry Lex, I've got your back on the simulation theory as a thought experiment that helps me (as a junior programmer) to abstract the idea of things such as math and physics.
Huge thanks for incredible Manolis and yourself 😁 loved the show!
9:55
We are brothers but unique
this is one of the best things I've ever heard
Man. Lex makes me feel like a spoiled chimp. Keep up brother.
22:45 "Wikipedia is pretty awesome." It is if you are a leftie shilling for the oligarchy, which is so controlling you can't even mention their name without getting censored and kicked off social media.
This is one of the best in a playlist of bests. Thanks Lex and Manolis
woah manolis 1 million years ago we were homo erectus. quite human-like and very far from a chimpanzee
Has he changed his views on origins of COVID-19?
molis eida tixaia video me tin stai prin 10 xronia kai mou petakse kai auto ahahaa
52:44 The asteroid did not strike "slightly north of Machu Picchu". The asteroid struck on the Yucatan Peninsula, slightly north of where the Mayan empire eventually arose in modern-day Mexico. Machu Picchu was built by the Incas, who lived thousands of miles away in the mountains of South America. Not even the same continent.
Not particularly important to the podcast, but the historical inaccuracy annoys me. Especially when it comes to how little people seem to know or care about pre-Colombian American civilizations.
6:03 what's unique about the genome?
16:43 effectively using the internet- teaching the basic "how-to"
23:10 why is wikipedia hated so much?
-ascertainment bias and writing bias
(implications?)
27:58 easier to figure the phenotype of something by mining this massive amount of human data than by going back to any other specie
(reason?)
29:15 free will?
continue from 37:00
Wow!!!
Being scientists cannot find the conscious particle, then is mind not a material entity?
I have sat at Plato's feet.
"I am extremely grateful and feel extremely lucky to be living in the time that we are now. And, of all time in human history, this is probably the best time to be a human being and this might actually be the best way to be a human being."
Completely accurate 💯👌🏽😌🥰🤩🌼🐛🌙🌟🌻😍🐝🦋🌷🥀🦄🐞🌸🌹✨💐
As far as I know the placebo response mechanism is because of the relaxation response
he is so gifted in biology and also gorgeous
Manolis Kellis inspires me! Love this guy.
Does it mean that if we put our brain in a body that for examples has 1 leg and 1 eye, or 4 arms and 10 legs, it will still find a way to control them and it'll become a valuable human that will fit in a society of similar "creatures"
He looks like the brother on good time